Julián Martínez Fernández4 months ago

Necrotizing Fasciitis

Necrotizing fasciitis (NF) is a life-threatening surgical emergency. It is a severe, potentially fatal infectious disease which rapidly extends from the subcutaneous tissue along the superficial and deep fascia causing vascular occlusion, ischemia, and necrosis of tissues. Bacterial endotoxins with the release of cytokines are mediators of rapid tissue destruction and have a crucial role in progression of the disease. The definitive diagnosis is made after surgical debridement with microbiologic and histological examination of infected tissues. Early recognition, determination of the extent of necrosis, appropriate aggressive therapy, and intensive care support are the most important predictors of survival in patients with NF.