陈坚 - 江南大学 - 生物工程学院

个人简介

1984年获清华大学环境工程专业学士学位 1986年无锡轻工业学院发酵工程专业硕士 1990年无锡轻工业学院发酵工程专业博士 2005年至2020年2月，担任江南大学校长

研究领域

长期从事发酵工程和食品生物技术的教学与研究工作，包括从细胞工厂构建体系与方法、发酵过程工程理论与技术两方面进行深入研究，改进发酵微生物高通量筛选系统、DNA多区域快速组合编辑和组装方法，发展氮代谢阻遏效应、酶表达与分泌偶联和代谢网络动态平衡等理论，开发多参数分析建模、在线检测、实时评估的发酵优化控制技术，实施典型有机酸、酶制剂和功能糖等工业发酵生产的过程强化、单元替代和流程重构

近期论文

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Xiaolong Zhang, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen. Microbial production of sialic acid and sialylated human milk oligosaccharides: Advances and perspectives. Biotechnology Advances, 2019, 37:787–800. Rongzhen Tian, Yanfeng Liu, Junrong Chen, Jianghua Li, Long Liu, Guocheng Du, Jian Chen. Synthetic N-terminal coding sequences for fine-tuning gene expression and metabolic engineering in Bacillus subtilis. Metabolic Engineering, 2019, 55: 131–141. Zheng Peng, Juan Zhang, Guocheng Du, Jian Chen. Keratin waste recycling based on microbial degradation: Mechanisms and prospects. ACS Sustainable Chemistry & Engineering. 2019, 7: 9727−9736. Weiping Zhang, Guocheng Du, Jingwen Zhou, Jian Chen. Regulation of sensing, transportation, and catabolism of nitrogen sources in Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews, 2018, 82(1): e00040-17. Yanfeng Liu, Hannes Link, Long Liu, Guocheng Du, Jian Chen, Uwe Sauer. A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis. Nature Communications, 2016, 7:11933. Peng Jin, Zhen Kang, Panhong Yuan, Guocheng Du, Jian Chen. Production of specificmolecular-weight hyaluronan by metabolically engineered Bacillus subtilis 168. Metabolic Engineering, 2016, 35:21-30. Junjun Wu, Guocheng Du, Jingwen Zhou, Jian Chen. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy. Metabolic Engineering, 2013, 16:48-55. Liming Liu, Yin Li, Yang Zhu, Guocheng Du, Jian Chen. Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metabolic Engineering, 2007, 9:21-29. Xian Yin, Jianghua Li, Hyun-dong Shin, Guoheng Du, Long Liu, Jian Chen. Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects. Biotechnology Advances, 2015, 33: 830-841. Jingwen Zhou, Guocheng Du, Jian Chen. Novel fermentation processes for manufacturing plant natural products. Current Opinion in Biotechnology, 2014. 25: 17-23.