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个人简介

教育经历 1986.9 - 1991.7 中国药科大学中药学院 1981.9 - 1986.7 上海医科大学药学院 工作经历 2019.9 - 目前 复旦大学天然药物学系 主任、教授、博导 2006.10 - 2006.11 日本九州大学药学院 访问教授 2002.1 - 2002.7 美国北卡罗莱纳大学药学院 访问教授 1999.3 - 2019.8 复旦大学生药学教研室 主任、博导 1998.2 - 1999.1 美国阿拉巴马大学伯明翰分校 访问学者 1997.7– 2019.8 复旦大学生药学教研室 教授 1995.3 - 2005.9 复旦大学药学院 副院长 1993.12 - 1997.6 上海医科大学生药学教研室 副教授 1991.7 - 1993.11 上海医科大学生药学教研室 讲师 1991.7 - 1993.10 上海医科大学生药学教研室 讲师 获奖及荣誉 1992 国家科技进步一等奖(鸡血藤类专题研究第1名) 2007 教育部高等学校科学技术奖自然科学一等奖(第一完成人)

研究领域

中草药活性成分及其资源(抗病毒、抗肿瘤、抗补体、抗氧化等) 常用中药材的品种整理、生药鉴定和质量评价 中药提取物和复方制剂的质量标准与新药研究

近期论文

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HJ Zhi, HY Zhu, YY Zhang, Y Lu, H Li, DF Chen*. In vivo Effect of Quantified Flavonoids-enriched Extract of Scutellaria baicalensis Root on Acute Lung Injury Induced by Influenza A Virus. Phytomedicine 2019, 57: 105-116 HY Zhu, XX Lu, LJ Ling, H Li, YY Ou, XL Shi, Y Lu, YY Zhang, DF Chen*. Houttuynia cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection. Journal of Ethnopharmacology 2018, 218: 90-99 Q Wen, Z Cao, Y Lu, DF Chen*. Anticomplement Triterpenoids from the Roots of Ilex asprella. Bioorg Med Chem Lett 2017, 27: 880-886 YY Ou, Y Jiang, H Li, YY Zhang, Y Lu, DF Chen*. Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats through Inhibiting Complement System. Inflammation 2017, 40(1): 275-284 P Jiang, Y Lu, DF Chen*. Authentication of Schisandra chinensis and Schisandra sphenanthera in Chinese Patent Medicines. J Pharm Biomed Anal 2016, 131: 263-271 ( SCI) DS Du, ZH Cheng, DF Chen*. Structure Characterization of Two Novel Polysaccharides Isolated from the Spikes of Prunella vulgaris and Their Anticomplement Activities. Journal of Ethnopharmacology 2016, 193: 345-353 M Yan, Y Lu,CH Chen,Y Zhao, KH Lee, DF Chen*. Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. J Nat Prod 2015, 78(11): 2712-2718 LY Pan, HB Weng, H Li, ZZ Liu, YY Xu, CJ Zhou, XX Lu, Xy Su, YY Zhang, DF Chen*. Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PLOS ONE 2015, 10(7): e0133212 YY Xu, YY Zhang, YY Ou, XX Lu, LY Pan, H Li, Y Lu, DF Chen*. Houttuynia cordata Thunb. Polysaccharides Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice. Journal of Ethnopharmacology 2015, 173: 81-90 WH Song, ZH Cheng, DF Chen*. Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa. J Nat Prod 2014, 77(1): 42-48 J Wu, YY Zhang, L Guo, H Li, DF Chen*. Bupleurum Polysaccharides Attenuates Lipopolysaccharide-induced Inflammation via Modulating Toll-Like Receptor 4 Signaling. PLOS ONE 2013, 8(10): e78051 JY Xie, H Li, HY Di, XQ Cheng, YY Zhang, DF Chen*. Bupleurum chinense DC Polysaccharides Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice. Phytomedicine 2012, 19(2): 130-137 XQ Cheng, H Li, XL Yue, JY Xie, YYZhang, HY Di, DF Chen*. Macrophage Immunomodulatory Activity of the Polysaccharides from the Roots of Bupleurum smithii var. parvifolium. Journal of Ethnopharmacology 2010, 130(2): 363-368 Q Wang, TH Chen, KF Bastow, KH Lee, DF Chen*. Altaicalarins A-D, Cytotoxic Bisabolane Sesquiterpenes from Ligularia altaica. J Nat Prod 2010, 73(2): 139-142 WH Ma, Y Lu, H Huang, P Zhou, DF Chen*. Schisanwilsonins A-G and Related Anti-HBV Lignans from the Fruits of Schisandra wilsoniana. Bioorg Med Chem Lett 2009, 19(17): 4958-4962 WH Ma, H Huang, P Zhou, DF Chen*. Schisanwilsonenes A-C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana. J Nat Prod 2009, 72(4): 676-678 Y Lu, DF Chen*. Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A 2009, 1216(11): 1980-1990 T Zhang, DF Chen*. Anticomplementary Principles of a Chinese Multiherb Remedy for the Treatment and Prevention of SARS. Journal of Ethnopharmacology 2008, 117(2): 351-361 H Xu, YY Zhang, JW Zhang, DF Chen*.Isolation and Characterization of an Anti-complementary Polysaccharide D3-S1 from the Roots of Bupleurum smithii. International Immunopharmacology 2007, 7(2):175-182 M Chen, N. Kilgore, KH Lee, DF Chen*. Rubrisandrins A and B, Lignans and Related Anti-HIV Compounds from Schisandra rubriflora. J Nat Prod 2006, 69(12):1697-1701 PL Ding, ZX Liao, H Huang, P Zhou, DF Chen*. (+)-12a-Hydroxysophocarpine, a New Quinolizidine Alkaloid and Related Anti-HBV Alkaloids from Sophora flavescens. Bioorg Med Chem Lett 2006, 16(5): 1231-1235 YQ Yu, PL Ding, DF Chen*. Determination of Quinolizidine Alkaloids in Sophora Medicinal Plants by Capillary Electrophoresis. Analytica Chimica Acta 2004, 523(1): 15-20 DF Chen*, SX Zhang, M Kozuka, QZ Sun, J Feng, Q Wang, T Mukainaka, Y Nobukuni, H Tokuda, H Nishino, HK Wang, SL Morris-Natschke, KH Lee. Interiotherins C and D, Two New Lignans from Kadsura interior and Antitumor-promoting Effects of Related Neolignans on Epstein-Barr Virus Activation. J Nat Prod 2002, 65(9):1242-1245 DF Chen*, SX Zhang, HK Wang, SY Zhang, QZ Sun, LM Cosentino and KH Lee. Novel Anti-HIV Lancilactone C and Related Triterpenes from Kadsura lancilimba. J Nat Prod 1999, 62(1): 94 -97 DF Chen*, SX Zhang, L Xie, JX Xie, K Chen, Y Kashiwada, BN Zhou, P Wang, LM Cosentino and KH Lee. Anti-AIDS Agents 26. Structure-Activity Correlations of Gomisin G-Related Anti-HIV Lignans from Kadsura interior and of Related Synthetic Analogues. Bioorg Med Chem 1997, 5(8):1715-1723 DF Chen*, SX Zhang, K Chen, BN Zhou, P Wang, LM Cosentino and KH Lee. Two New Lignans, Interiotherins A and B, as Anti-HIV Principles from Kadsura interior. J Nat Prod 1996, 59(11): 1066-1068

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