CN101297989B - 基于模压的中空微针批量制备方法 - Google Patents

基于模压的中空微针批量制备方法 Download PDF

Info

Publication number
CN101297989B
CN101297989B CN 200810039184 CN200810039184A CN101297989B CN 101297989 B CN101297989 B CN 101297989B CN 200810039184 CN200810039184 CN 200810039184 CN 200810039184 A CN200810039184 A CN 200810039184A CN 101297989 B CN101297989 B CN 101297989B
Authority
CN
China
Prior art keywords
micropin
mold pressing
thin plate
hollow
microneedle array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 200810039184
Other languages
English (en)
Chinese (zh)
Other versions
CN101297989A (zh
Inventor
刘景全
沈修成
王亚军
杨春生
陈迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Jiaotong University
Original Assignee
Shanghai Jiaotong University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Jiaotong University filed Critical Shanghai Jiaotong University
Priority to CN 200810039184 priority Critical patent/CN101297989B/zh
Publication of CN101297989A publication Critical patent/CN101297989A/zh
Application granted granted Critical
Publication of CN101297989B publication Critical patent/CN101297989B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
CN 200810039184 2008-06-19 2008-06-19 基于模压的中空微针批量制备方法 Expired - Fee Related CN101297989B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200810039184 CN101297989B (zh) 2008-06-19 2008-06-19 基于模压的中空微针批量制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200810039184 CN101297989B (zh) 2008-06-19 2008-06-19 基于模压的中空微针批量制备方法

Publications (2)

Publication Number Publication Date
CN101297989A CN101297989A (zh) 2008-11-05
CN101297989B true CN101297989B (zh) 2010-06-23

Family

ID=40078023

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200810039184 Expired - Fee Related CN101297989B (zh) 2008-06-19 2008-06-19 基于模压的中空微针批量制备方法

Country Status (1)

Country Link
CN (1) CN101297989B (un)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
EP2247527A4 (en) 2008-02-07 2014-10-29 Univ Queensland PATCH PRODUCTION
CA2760680A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents
EP2379160B1 (en) * 2008-12-22 2014-09-10 The University Of Queensland Patch production
US9289925B2 (en) * 2009-04-10 2016-03-22 3M Innovative Properties Company Methods of making hollow microneedle arrays and articles and uses therefrom
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
CN102000020B (zh) * 2010-11-17 2012-10-10 河南羚锐制药股份有限公司北京药物研究院 新型可降解聚合物微针贴剂及其制备方法
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
CN102836936B (zh) * 2012-08-30 2014-12-24 上海交通大学 用于透皮给药的钛实心微针的制备方法
CA3204959A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CN104844814A (zh) * 2015-05-29 2015-08-19 北京化工大学 一种微针模板及其制备方法
CN105031744B (zh) * 2015-06-29 2018-01-02 苏州大学 一种增生性瘢痕用微针及其制备方法
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
WO2018176102A1 (en) 2017-03-31 2018-10-04 Vaxxas Pty Limited Device and method for coating surfaces
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
EP4218893A1 (en) 2017-08-04 2023-08-02 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP6965068B2 (ja) * 2017-09-13 2021-11-10 花王株式会社 中空突起具の製造方法、中空突起具の製造装置、及び中空突起具
WO2019111959A1 (ja) * 2017-12-05 2019-06-13 古河電気工業株式会社 機能性部材及びその製造方法
CN109529186B (zh) * 2018-12-17 2021-05-11 广东工业大学 一种药物涂层非晶合金微针及其制作方法
CN113509638A (zh) * 2021-05-18 2021-10-19 华东师范大学 一种带微孔的微针阵列及其制备方法
CN115400341B (zh) * 2022-08-30 2024-02-02 华中科技大学 一种可溶性聚合物微针及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1526454A (zh) * 2003-03-06 2004-09-08 财团法人工业技术研究所 微针头阵列制造方法
CN1541724A (zh) * 2003-11-04 2004-11-03 浙江大学 一种用于药物控释的微针阵列
CN1555893A (zh) * 2003-12-30 2004-12-22 上海交通大学 基于三维微细加工工艺的批量加工微探针的方法
WO2006101459A1 (en) * 2005-03-23 2006-09-28 Agency For Science, Technology And Research Microneedles
CN1864976A (zh) * 2006-04-06 2006-11-22 上海交通大学 基于多层加工技术的微针制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1526454A (zh) * 2003-03-06 2004-09-08 财团法人工业技术研究所 微针头阵列制造方法
CN1541724A (zh) * 2003-11-04 2004-11-03 浙江大学 一种用于药物控释的微针阵列
CN1555893A (zh) * 2003-12-30 2004-12-22 上海交通大学 基于三维微细加工工艺的批量加工微探针的方法
WO2006101459A1 (en) * 2005-03-23 2006-09-28 Agency For Science, Technology And Research Microneedles
CN1864976A (zh) * 2006-04-06 2006-11-22 上海交通大学 基于多层加工技术的微针制备方法

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
JP特表2007-523771A 2007.08.23
Mark R. Prausnitz.Microneedles for Transdermal Drug Delivery.Advanced Drug Delivery Reviews56.2004,56581-587. *
Mit suhiro Shikida , Takehiko Hasada , Kazuo Sato.Fabrication of a Hollow Needles St ructure by Dicing , WetEtching and Metal Deposition.Journal of Micromechanics and Microngineering16.2006,162230-2239.
Mit suhiro Shikida, Takehiko Hasada, Kazuo Sato.Fabrication of a Hollow Needles St ructure by Dicing, WetEtching and Metal Deposition.Journal of Micromechanics and Microngineering16.2006,162230-2239. *
孙潇，贾书海，朱军，李以贵.新型MEMS微针设计及其力学性能.半导体学报28 1.2007,28(1),113-116.
孙潇,贾书海,朱军,李以贵.新型MEMS微针设计及其力学性能.半导体学报28 1.2007,28(1),113-116. *
许宝建，金庆辉，赵建龙.基于MEMS微针技术的研究现状与展望.MEMS器件与技术 4.2005,(4),150-156.
许宝建,金庆辉,赵建龙.基于MEMS微针技术的研究现状与展望.MEMS器件与技术 4.2005,(4),150-156. *
边佳明 ，曾明，许景峰.微针在经皮给药领域的研究进展.中国药学杂志41 16.2006,41(16),1209-1211，1224.
边佳明,曾明,许景峰.微针在经皮给药领域的研究进展.中国药学杂志41 16.2006,41(16),1209-1211,1224. *

Also Published As

Publication number Publication date
CN101297989A (zh) 2008-11-05

Similar Documents

Publication Publication Date Title
CN101297989B (zh) 基于模压的中空微针批量制备方法
Larrañeta et al. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Ali et al. Transdermal microneedles—a materials perspective
US8043250B2 (en) High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8048017B2 (en) High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
Bariya et al. Microneedles: an emerging transdermal drug delivery system
Donnelly et al. Microneedle-mediated transdermal and intradermal drug delivery
Donnelly et al. Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety
US6749792B2 (en) Micro-needles and methods of manufacture and use thereof
TW425294B (en) Intracutaneous edged microneedle apparatus
EP2056921B1 (en) High-aspect-ratio microdevices for transdermal delivery and sampling of active substances
Xue et al. Blood sampling using microneedles as a minimally invasive platform for biomedical diagnostics
JP2002517300A (ja) 微小針デバイスおよび製造方法ならびにそれらの使用
Singh et al. Microneedles for drug delivery and monitoring
Cheng et al. Recent progress of micro-needle formulations: Fabrication strategies and delivery applications
Luo et al. Microneedles: materials, fabrication, and biomedical applications
KR102367746B1 (ko) 경피 투입형 약물 패치 마이크로 니들 제조 방법
CN1287872C (zh) 一种气囊控制的微量药物输送执行器
Mishra et al. MEMS-based hollow microneedles for transdermal drug delivery
Singh et al. Fabrication of microneedles
Tabassum et al. Microneedle technology: a new drug delivery system
Moffatt et al. Microneedle technology
CN114939100A (zh) 一种高密度任意曲面聚合物微针阵列及其制备方法与应用
Azizi Machekposhti et al. Microneedle fabrication methods and applications
McAlister et al. Microneedles for drug delivery and monitoring

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20100623

Termination date: 20130619