夏玉先，1964年生，重庆大学生命科学学院教授（二级）、博士生导师、生物学一级学科博士点学术带头人、教育部“新世纪优秀人才”、重庆市百名杰出科技领军人才、重庆市微生物学科带头人、《中国生物防治学报》副主编、农业农村部专家指导委员会委员、国家标准委员会生物农药分委会副秘书长。 现任重庆大学基因工程研究中心主任、重庆市“杀虫真菌农药工程技术研究中心”主任、重庆市功能基因与调控技术重点实验室主任。主要从事杀虫真菌农药研制相关的基础研究和应用技术研究。先后主持国家级和省部级科研、中试和产业化项目20多项；主持完成的研究成果获2009年度重庆市技术发明一等奖和2010年获中国侨界贡献奖（创新成果），获得国家发明专利20项。以第一或通讯作者在PLoS Genetics, Environmental Microbiology, Microbiology-SGM, BMC Genomics，Applied Microbiology and Biotechnology等著名学术刊物发表SCI收录论文60多篇；获得国家发明专利20项。
- 中文名
- 夏玉先
- 毕业院校
- 英国Bath大学
- 学位/学历
- 博士
- 专业方向
- 分子微生物学、昆虫病理学、微生物分子育种
- 职 务
- 重庆大学基因工程研究中心主任
1997套船姜-20阀盛删催嫌乐洒00重立 英国Bath键堡大学 获博士学位（英国海外研究学生奖学金）
1996-1997 英国Bath舟拘翻大学访问学者（中英友好奖学金）
19劝恋91-1997 西南大学 历任助教、讲师、副教授
2000-至今 重庆大晚埋坑学 教授 [1]
围绕杀虫真菌农药创制，以绿僵菌和东亚飞蝗为模式，开展昆虫病原真菌重要性状（产孢、致病、抗逆）形成的分子机制，发掘功能基因及调控方法（分子微生物学方向）；阐明昆虫防卫病原真菌侵染的分子机制，发现新的杀虫靶标及害虫防控新途径（昆虫病理学方向）；开展杀虫真菌菌株选育新技术研究，选育高产、抗逆和高杀虫活性的菌株（微生物分子育种方向）。 [1]
博士研究生：生物科学研究前沿
硕士研究生：专业英语
中国留学基金委终身评委。 [1]
【1】Zhang E。 , Cao Y., Xia Y。 Ethanol dehydrogenase I contributes to growth and sporulation under low oxygen condition via detoxification of
acetaldehyde in Metarhiziumacridum，Front. Microbiol.2018，9:1932
【2】Li G., Fan A., Peng G., Keyhani NO., Xin J., Cao Y. Xia Y，A bifunctional catalase-peroxidase, MakatG1, contributes to virulence of
Metarhizium acridum by overcoming oxidative stress on the host insect cuticle，Environ Microbiol，2017,19(10): 4365–4378
【3】Zhang W, Chen J, Keyhani NO, Jin K, Wei Q, Xia Y，Central Nervous System Responses of the Oriental migratory, Locusta migratoria manilensis,
to Fungal Infection.Sci Rep.2017 ;7(1):1034
【4】Zhang J,Jin K, Xia Y,Contributions of β-tubulin to cellular morphology, sporulation and virulence in the insect-fungal pathogen, Fungal Genet
Biol.2017, 103:16-24
【5】Hong M.，Peng G., Keyhani NO, Xia Y.Application of the entomogenous fungus, Metarhizium anisopliae, for leafroller (Cnaphalocrocis medinalis)
control and its effect on rice phyllosphere microbial diversity，Appl Microbiol Biotechnol，2017,101:6793–6807
【6】Hu J, Xia Y.Increased virulence in the locust-specific fungal pathogen Metarhizium acridum expressing dsRNAs targeting the host F1 F0 -ATPase
subunit genes.Pest Manag Sci，2018 May 23. doi: 10.1002/ps.5085
【7】Hu J, Xia Y.F1-ATP synthase α subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis.Pest Manag
Sci2016, 72:1433- 1439
【8】 Wang ZL, Jin K, Xia YX. Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in
response to different nutrients. BMC Genomics. 2016, 17: 586.
【9】 Zhang W., Wanchoo A., Ortiz-Urquiza., Yuxian Xia, and Nemat O. Keyhani. Tissue, developmental, and caste-specific expression of
odorant binding proteins in a eusocial insect, the red imported fire ant, Solenopsis invicta. Scientific Reports, 2016, 6.
【10】 Jin K, Peng GX, Liu YC, Xia YX. The acid trehalase, ATM1, contributes to the in vivo growth and virulence of the entomopathogenic fungus,
Metarhizium acridum. Fungal Genetics and Biology. 2015, 77: 61-67.
【11】 Ma QS, Jin K, Peng GX, Xia YX. An ENA ATPase, MaENA1, of Metarhizium acridum influences the Nai+-, thermo- and UV-tolerances of conidia and
is involved in multiple mechanisms of stress tolerance. Fungal Genetics and Biology.2015, 83: 68-77.
【12】 Peng GX, Jin K, Liu YC, Xia YX. Enhancing the utilization of host trehalose by fungal trehalase improves the virulence of fungal
insecticide. Applied Microbiology and Biotechnology. 2015, 99(20):8611-8618.
【13】 Zhang W, Chen J, Keyhani NO, Zhang Z, Li S, Xia Y. Comparative transcriptomic analysis of immune responses of the migratory locust, Locusta
migratoria, to challenge by the fungal insect pathogen, Metarhizium acridum. BMC genomics 2015, 16: 867-
【14】 Ming Y, Wei QL, Jin K, Xia YX. MaSnf1, a sucrose non-fermenting protein kinase gene, is involved in carbon source utilization, stress
tolerance and virulence in Metarhizium acridum. Applied Microbiology and Biotechnology. 2014, 98: 10153-10164.
【15】 Cao Y., Du M., Luo S., Xia Y. Calcineurin modulates growth, stress tolerance, and virulence in Metarhizium acridum and its regulatory
network. Applied Microbiology and Biotechnology. 2014, 98: 8253-8265
【16】 Zhang W., Xia Y. ER type I signal peptidase subunit (LmSPC1) is essential for the survival of Locusta migratoria manilensis and
affects moulting, feeding, reproduction and embryonic development. Insect molecular biology, 2014, 23(3): 269-285.
【17】 Jin K, Han LR, and Xia YX. MaMk1, a FUS3/KSS1-type mitogen-activated protein kinase gene, is required for appressorium formation, and
insect cuticle penetration of the entomopathogenic fungus Metarhizium acridum. Journal of Invertebrate Pathology. 2014, 115(1): 68-75.
【18】 Luo S., He M, Cao Y, Xia Y. The tetraspanin gene MaPls1 contributes to virulence by affecting germination, appressorial function and
enzymes for cuticle-degradation in the entomopathogenic fungus, Metarhizium acridium. Environmental Microbiology 2013, 15 (11): 2966-2979.
【19】 Jin K, Ming Y, and Xia YX. MaHog1, a Hog1-type mitogen-activated protein kinase gene, contributes to stress tolerance and virulence of the
entomopathogenic fungus Metarhizium acridum. Microbiology-SGM. 2012, 158(12): 2987-2996.
【20】 Cao Y., Zhu X., Jiao R., Xia Y. The Magas1 gene is involved in pathogenesis by affecting penetration in Metarhizium acridum. Journal of
Microbio1ogy and Biotechnology. 2012, 22: 889–893 .
【21】 Cao Y., Jiao R., Xia Y. A strong promoter, PMagpd, provides a tool for high gene expression in entomopathogenic fungus, Metarhizium acridum.
Biotechnology letters, 2012, 34: 557 – 562.
【22】 Gao Q, Jin K, Ying S, Zhang Y, Xiao G, Shang Y, Duan Z, Hu X, Xie X, Zhou G, Peng G, Luo Z, Huang W, Wang B, Fang W, Wang S, Zhong Y, Ma L,
St. Leger RJ, Zhao G, Pei Y, Feng M*, Xia Y*, Wang C* Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi
Metarhizium anisopliae and M. acridum. PLoS Genet., 2011, 7: e1001264.
【23】 Jin K, Zheng X, Xia Y. Gene expression profiling via multigene concatemers. PLoS One. 2011, 6:e15711.
【24】 Cao Y., Li M., Xia Y. Mapmi contributes to growth, stress tolerance and virulence of the entomopathogenic fungus Metarhizium acridum, J.
Invert. Pathol., 2011, 108: 7-12.
【25】 Cao Y., Li K., Xia Y. Down-regulation of the pre-rRNA processing gene Mamrd1 decreases growth and virulence in the entomopathogenic fungus,
Metarhizium acridum. Res Microbiol, 2011, 162: 729-736.
【26】 Yang M, Jin K, Xia Y. MaFKS, a β-1,3-glucan synthase, is involved in cell wall integrity, hyperosmotic pressure tolerance and conidiation
in Metarhizium acridum. Curr Genet., 2011, 57:253-260.
【27】 Zheng XL. Xia YX. β-1,3-Glucan recognition protein (βGRP) is essential for resistance against fungal pathogen and opportunistic
pathogenic gut bacteria in Locusta migratoria manilensis. Developmental & Comparative Immunology, 2011, 36(3):602-609.
【28】 Leng YJ, Peng GX, Cao YQ, Xia YX (2011) Genetically altering the expression of neutral trehalase gene affects conidiospore thermotolerance
of the entomopathogenic fungus Metarhizium acridum. BMC Microbiology. 2011, 11:32
【39】 Zhang S, Xia Y, Kim B Keyhani NO. Two hydrophobins are involved in fungal spore coat rodlet layer assembly and each play distinct roles in
surface interactions, development and pathogenesis in the entomopathogenic fungus, Beauveria bassiana. Mol. Microbiol. 2011, 80:811-826.
【30】 Zhang C, Xia Y, Li Z. Identification of genes differentially expressed by Metarhizium anisopliae growing on Locusta migratoria wings using
suppression subtractive hybridization. Curr Microbiol. 2011, 62(5):1649-55.
【31】 Zhou X, Xia Y. Expression and characterization of recombinant Locusta migratoria manilensis acetylcholinesterase 1 in Pichia pastoris.
Protein Expr Purif. 2011, 77:62-67.
【32】 Peng GX, Xia YX. The mechanism of the mycoinsecticide diluent on the efficacy of the oil formulation of insecticidal fungus. Biocontrol,
2011, 56:893–902 [1]
2009年主持完成的研究成果获重庆市技术发明一等奖；
